NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction

The bioenergetics and molecular determinants of the metabolic response to mitochondrial dysfunction are incompletely understood, in part due to a lack of appropriate isogenic cellular models of primary mitochondrial defects. Here, we capitalize on a recently developed cell model with defined levels...

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Detalles Bibliográficos
Autores principales: Gaude, Edoardo, Schmidt, Christina, Gammage, Payam A., Dugourd, Aurelien, Blacker, Thomas, Chew, Sew Peak, Saez-Rodriguez, Julio, O’Neill, John S., Szabadkai, Gyorgy, Minczuk, Michal, Frezza, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823973/
https://www.ncbi.nlm.nih.gov/pubmed/29452638
http://dx.doi.org/10.1016/j.molcel.2018.01.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823973/
https://www.ncbi.nlm.nih.gov/pubmed/29452638
http://dx.doi.org/10.1016/j.molcel.2018.01.034

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