Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations

The unmet medical need of providing evidence‐based pharmacotherapy for pregnant women is recognized by the regulatory bodies. Physiologically based pharmacokinetic (PBPK) modeling offers an attractive platform to quantify anticipated changes in the pharmacokinetics (PKs) of drugs during pregnancy. R...

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Detalles Bibliográficos
Autores principales: Ke, Alice Ban, Greupink, Rick, Abduljalil, Khaled
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824116/
https://www.ncbi.nlm.nih.gov/pubmed/29349870
http://dx.doi.org/10.1002/psp4.12274
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author Ke, Alice Ban
Greupink, Rick
Abduljalil, Khaled
author_facet Ke, Alice Ban
Greupink, Rick
Abduljalil, Khaled
author_sort Ke, Alice Ban
collection PubMed
description The unmet medical need of providing evidence‐based pharmacotherapy for pregnant women is recognized by the regulatory bodies. Physiologically based pharmacokinetic (PBPK) modeling offers an attractive platform to quantify anticipated changes in the pharmacokinetics (PKs) of drugs during pregnancy. Recent publications applying a pregnancy PBPK module to the prediction of maternal and fetal exposure of drugs are summarized. Future opportunities to use PBPK models to predict breast milk exposure and assess human fetotoxicity risks are presented.
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spelling pubmed-58241162018-02-26 Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations Ke, Alice Ban Greupink, Rick Abduljalil, Khaled CPT Pharmacometrics Syst Pharmacol Reviews The unmet medical need of providing evidence‐based pharmacotherapy for pregnant women is recognized by the regulatory bodies. Physiologically based pharmacokinetic (PBPK) modeling offers an attractive platform to quantify anticipated changes in the pharmacokinetics (PKs) of drugs during pregnancy. Recent publications applying a pregnancy PBPK module to the prediction of maternal and fetal exposure of drugs are summarized. Future opportunities to use PBPK models to predict breast milk exposure and assess human fetotoxicity risks are presented. John Wiley and Sons Inc. 2018-01-31 2018-02 /pmc/articles/PMC5824116/ /pubmed/29349870 http://dx.doi.org/10.1002/psp4.12274 Text en © 2018 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Reviews
Ke, Alice Ban
Greupink, Rick
Abduljalil, Khaled
Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations
title Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations
title_full Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations
title_fullStr Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations
title_full_unstemmed Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations
title_short Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations
title_sort drug dosing in pregnant women: challenges and opportunities in using physiologically based pharmacokinetic modeling and simulations
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824116/
https://www.ncbi.nlm.nih.gov/pubmed/29349870
http://dx.doi.org/10.1002/psp4.12274
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