Association of Mismatch Repair Mutation With Age at Cancer Onset in Lynch Syndrome: Implications for Stratified Surveillance Strategies

IMPORTANCE: Lynch syndrome is caused by dominantly inherited germline mutations that predispose individuals to colorectal, endometrial, ovarian, and other cancers through inactivation of the cellular mismatch repair system. Lynch syndrome–associated cancers are amenable to surveillance strategies th...

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Detalles Bibliográficos
Autores principales: Ryan, Neil A. J., Morris, Julie, Green, Kate, Lalloo, Fiona, Woodward, Emma R., Hill, James, Crosbie, Emma J., Evans, D. Gareth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824283/
https://www.ncbi.nlm.nih.gov/pubmed/28772289
http://dx.doi.org/10.1001/jamaoncol.2017.0619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824283/
https://www.ncbi.nlm.nih.gov/pubmed/28772289
http://dx.doi.org/10.1001/jamaoncol.2017.0619

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