TAT‐MTS‐MCM fusion proteins reduce MMA levels and improve mitochondrial activity and liver function in MCM‐deficient cells

Methylmalonic aciduria (MMA) is a disorder of organic acid metabolism resulting from a functional defect of the mitochondrial enzyme, methylmalonyl‐CoA mutase (MCM). The main treatments for MMA patients are dietary restriction of propiogenic amino acids and carnitine supplementation. Liver or combin...

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Detalles Bibliográficos
Autores principales: Erlich‐Hadad, Tal, Hadad, Rita, Feldman, Anat, Greif, Hagar, Lictenstein, Michal, Lorberboum‐Galski, Haya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824393/
https://www.ncbi.nlm.nih.gov/pubmed/29265583
http://dx.doi.org/10.1111/jcmm.13435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824393/
https://www.ncbi.nlm.nih.gov/pubmed/29265583
http://dx.doi.org/10.1111/jcmm.13435

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