Co-occurring expression and methylation QTLs allow detection of common causal variants and shared biological mechanisms

Inherited genetic variation affects local gene expression and DNA methylation in humans. Most expression quantitative trait loci (cis-eQTLs) occur at the same genomic location as a methylation QTL (cis-meQTL), suggesting a common causal variant and shared mechanism. Using DNA and RNA from peripheral...

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Detalles Bibliográficos
Autores principales: Pierce, Brandon L., Tong, Lin, Argos, Maria, Demanelis, Kathryn, Jasmine, Farzana, Rakibuz-Zaman, Muhammad, Sarwar, Golam, Islam, Md. Tariqul, Shahriar, Hasan, Islam, Tariqul, Rahman, Mahfuzar, Yunus, Md., Kibriya, Muhammad G., Chen, Lin S., Ahsan, Habibul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824840/
https://www.ncbi.nlm.nih.gov/pubmed/29476079
http://dx.doi.org/10.1038/s41467-018-03209-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824840/
https://www.ncbi.nlm.nih.gov/pubmed/29476079
http://dx.doi.org/10.1038/s41467-018-03209-9

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