BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

HIV-1 latent reservoirs harbouring silenced but replication-competent proviruses are a major obstacle against viral eradication in infected patients. The “shock and kill” strategy aims to reactivate latent provirus with latency reversing agents (LRAs) in the presence of antiretroviral drugs, necessi...

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Detalles Bibliográficos
Autores principales: Gohda, Jin, Suzuki, Kazuo, Liu, Kai, Xie, Xialin, Takeuchi, Hiroaki, Inoue, Jun-ichiro, Kawaguchi, Yasushi, Ishida, Takaomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824842/
https://www.ncbi.nlm.nih.gov/pubmed/29476067
http://dx.doi.org/10.1038/s41598-018-21942-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824842/
https://www.ncbi.nlm.nih.gov/pubmed/29476067
http://dx.doi.org/10.1038/s41598-018-21942-5

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