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BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

HIV-1 latent reservoirs harbouring silenced but replication-competent proviruses are a major obstacle against viral eradication in infected patients. The “shock and kill” strategy aims to reactivate latent provirus with latency reversing agents (LRAs) in the presence of antiretroviral drugs, necessi...

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Detalles Bibliográficos
Autores principales:	Gohda, Jin, Suzuki, Kazuo, Liu, Kai, Xie, Xialin, Takeuchi, Hiroaki, Inoue, Jun-ichiro, Kawaguchi, Yasushi, Ishida, Takaomi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824842/ https://www.ncbi.nlm.nih.gov/pubmed/29476067 http://dx.doi.org/10.1038/s41598-018-21942-5

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