STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles

A subset of human follicular helper T cells (TFH) cells expresses CD57 for which no distinct function has been identified. We show that CD57+ TFH cells are universally PD-1(hi), but compared to their CD57− PD-1(hi) counterparts, express little IL-21 or IL-10 among others. Instead, CD57 expression on...

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Detalles Bibliográficos
Autores principales: Alshekaili, Jalila, Chand, Rochna, Lee, Cindy Eunhee, Corley, Susan, Kwong, Kristy, Papa, Ilenia, Fulcher, David A., Randall, Katrina L., Leiding, Jennifer W., Ma, Cindy S., Wilkins, Marc R., Uzel, Gulbu, Goodnow, Chris C., Vinuesa, Carola G., Tangye, Stuart G., Cook, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824848/
https://www.ncbi.nlm.nih.gov/pubmed/29476109
http://dx.doi.org/10.1038/s41598-018-21389-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824848/
https://www.ncbi.nlm.nih.gov/pubmed/29476109
http://dx.doi.org/10.1038/s41598-018-21389-8

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