Cargando…

Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity

Pro-opiomelanocortin (POMC) neurons function as key regulators of metabolism and physiology by releasing prohormone-derived neuropeptides with distinct biological activities. However, our understanding of early events in prohormone maturation in the ER remains incomplete. Highlighting the significan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Geun Hyang, Shi, Guojun, Somlo, Diane R.M., Haataja, Leena, Song, Soobin, Long, Qiaoming, Nillni, Eduardo A., Low, Malcolm J., Arvan, Peter, Myers, Martin G., Qi, Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824855/ https://www.ncbi.nlm.nih.gov/pubmed/29457782 http://dx.doi.org/10.1172/JCI96420

Ejemplares similares

Selective Restoration of Pomc Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network
por: Jones, Graham L., et al.
Publicado: (2019)

OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background
por: Gahlot, Surbhi, et al.
Publicado: (2020)

Hypothalamic POMC deficiency increases circulating adiponectin despite obesity
por: Yu, Hui, et al.
Publicado: (2020)

Glucose Rapidly Induces Different Forms of Excitatory Synaptic Plasticity in Hypothalamic POMC Neurons
por: Hu, Jun, et al.
Publicado: (2014)

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes
por: Yu, Hui, et al.
Publicado: (2022)

Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria
por: Chhabra, Kavaljit H., et al.
Publicado: (2016)

SAT-299 Chronic Treatment Of Juvenile Hypothalamic Pomc-deficient Mice With RM-493 Prevents The Development Of Obesity
por: Thompson, Zoe, et al.
Publicado: (2020)

Hypothalamic POMC or MC4R deficiency impairs counterregulatory responses to hypoglycemia in mice
por: Tooke, Benjamin P., et al.
Publicado: (2018)

Lactate activates hypothalamic POMC neurons by intercellular signaling
por: Órdenes, P., et al.
Publicado: (2021)

Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons
por: Burke, Luke K., et al.
Publicado: (2016)

PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones
por: Chen, Yu-Jie, et al.
Publicado: (2021)

Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression
por: Lage, Ricardo, et al.
Publicado: (2015)

Gene Expression and the Control of Food Intake by Hypothalamic POMC/CART Neurons
por: Hill, Jennifer W.
Publicado: (2010)

Defective regulation of POMC precedes hypothalamic inflammation in diet-induced obesity
por: Souza, Gabriela F. P., et al.
Publicado: (2016)

Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2
por: Zanesco, Ariane Maria, et al.
Publicado: (2022)

Upregulation of hypothalamic POMC neurons after biliary diversion in GK rats
por: Zhou, Shengnan, et al.
Publicado: (2022)

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
por: Chhabra, Kavaljit H., et al.
Publicado: (2016)

Pomc-expressing progenitors give rise to antagonistic populations in hypothalamic feeding circuits
por: Padilla, Stephanie L., et al.
Publicado: (2010)

Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3′UTR
por: Derghal, Adel, et al.
Publicado: (2015)

Olanzapine- induced metabolic syndrome pathogenesis: Hypothalamic “leptin resistance” or “pomc resistance”?
por: Veneziani, F., et al.
Publicado: (2021)

InsR/FoxO1 Signaling Curtails Hypothalamic POMC Neuron Number
por: Plum, Leona, et al.
Publicado: (2012)

Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Epigenomic and metabolic responses of hypothalamic POMC neurons to gestational nicotine exposure in adult offspring
por: Silva, Jose P., et al.
Publicado: (2016)

Maternal overnutrition programs epigenetic changes in the regulatory regions of hypothalamic Pomc in the offspring of rats
por: Gali Ramamoorthy, Thanuja, et al.
Publicado: (2018)

Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons
por: Varela, Luis, et al.
Publicado: (2017)

Chronic Restraint Stress Decreases the Excitability of Hypothalamic POMC Neuron and Increases Food Intake
por: Ha, Go Eun, et al.
Publicado: (2021)

Integration of ER protein quality control mechanisms defines β cell function and ER architecture
por: Shrestha, Neha, et al.
Publicado: (2023)

Over-Expression of Leptin Receptors in Hypothalamic POMC Neurons Increases Susceptibility to Diet-Induced Obesity
por: Gamber, Kevin M., et al.
Publicado: (2012)

Magel2 Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice
por: Mercer, Rebecca E., et al.
Publicado: (2013)

Correction: Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons
por: Ha, Sangdeuk, et al.
Publicado: (2013)

Anesthetic drugs modulate feeding behavior and hypothalamic expression of the POMC polypeptide precursor and the NPY neuropeptide
por: Besnier, E., et al.
Publicado: (2018)

MON-709 Single-Cell RNA-Sequencing Deciphers POMC Neuron Destiny
por: Yu, Hui, et al.
Publicado: (2020)

Hypoxia-Inducible Factor Directs POMC Gene to Mediate Hypothalamic Glucose Sensing and Energy Balance Regulation
por: Zhang, Hai, et al.
Publicado: (2011)

Proliferative Hypothalamic Neurospheres Express NPY, AGRP, POMC, CART and Orexin-A and Differentiate to Functional Neurons
por: Sousa-Ferreira, Lígia, et al.
Publicado: (2011)

Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling
por: Yuan, Feixiang, et al.
Publicado: (2020)

Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin
por: Perissinotti, Paula P., et al.
Publicado: (2021)

Metformin ameliorates olanzapine-induced disturbances in POMC neuron number, axonal projection, and hypothalamic leptin resistance
por: Kim, Jaedeok, et al.
Publicado: (2022)

Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits
por: Fang, Xing, et al.
Publicado: (2022)

Controlling hypothalamic DNA methylation at the Pomc promoter does not regulate weight gain during the development of obesity
por: McFadden, Taylor, et al.
Publicado: (2023)

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales
por: Mandelblat-Cerf, Yael, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_3vcfrj08jhvdslpvcsf936pjdo