A genetic variant in SLC30A2 causes breast dysfunction during lactation by inducing ER stress, oxidative stress and epithelial barrier defects

SLC30A2 encodes a zinc (Zn) transporter (ZnT2) that imports Zn into vesicles in highly-specialized secretory cells. Numerous mutations and non-synonymous variants in ZnT2 have been reported in humans and in breastfeeding women; ZnT2 variants are associated with abnormally low milk Zn levels and can...

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Detalles Bibliográficos
Autores principales: Lee, Sooyeon, Zhou, Yandong, Gill, Donald L., Kelleher, Shannon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824919/
https://www.ncbi.nlm.nih.gov/pubmed/29476070
http://dx.doi.org/10.1038/s41598-018-21505-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824919/
https://www.ncbi.nlm.nih.gov/pubmed/29476070
http://dx.doi.org/10.1038/s41598-018-21505-8

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