Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model

Phospholipase D (PLD) is a key player in the modulation of multiple aspects of cell physiology and has been proposed as a therapeutic target for Alzheimer’s disease (AD). Here, we characterize a PLD mutant, pld-1, using the Caenorhabditis elegans animal model. We show that pld-1 animals present decr...

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Detalles Bibliográficos
Autores principales: Bravo, Francisca Vaz, Da Silva, Jorge, Chan, Robin Barry, Di Paolo, Gilbert, Teixeira-Castro, Andreia, Oliveira, Tiago Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824944/
https://www.ncbi.nlm.nih.gov/pubmed/29476137
http://dx.doi.org/10.1038/s41598-018-21918-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824944/
https://www.ncbi.nlm.nih.gov/pubmed/29476137
http://dx.doi.org/10.1038/s41598-018-21918-5

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