Multiple lines of inhibitory feedback on AKT kinase in Schwann cells lacking TSC1/2 hint at distinct functions of mTORC1 and AKT in nerve development

During nerve development, Schwann cells (SCs) build multilayered myelin sheaths around axons to accelerate nerve conduction. The mechanistic target of rapamycin complex 1 (mTORC1) downstream of PI3K/AKT signaling lately emerged as a central anabolic regulator of myelination. Using mutant mice with s...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Keit Men, Beirowski, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824964/
https://www.ncbi.nlm.nih.gov/pubmed/29497474
http://dx.doi.org/10.1080/19420889.2018.1433441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824964/
https://www.ncbi.nlm.nih.gov/pubmed/29497474
http://dx.doi.org/10.1080/19420889.2018.1433441

Ejemplares similares