Zinc pyrithione activates K(+) channels and hyperpolarizes the membrane of rat pulmonary artery smooth muscle cells

The membrane potential helps determine pulmonary artery smooth muscle cell (PASMC) contraction. The Kv7 channel activators, retigabine and flupirtine, are thought to dilate pulmonary arteries by hyperpolarising PASMC. Zinc pyrithione activates Kv7 channels by a mechanism distinct from retigabine and...

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Detalles Bibliográficos
Autores principales: Eid, Basma G., Gurney, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824988/
https://www.ncbi.nlm.nih.gov/pubmed/29474372
http://dx.doi.org/10.1371/journal.pone.0192699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824988/
https://www.ncbi.nlm.nih.gov/pubmed/29474372
http://dx.doi.org/10.1371/journal.pone.0192699

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