Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells

Diabetic retinopathy (DR) is a major cause of adult blindness. Retinal Müller cells maintain water homeostasis and potassium concentration via inwardly rectifying Kir4.1 channels. Accumulation of advanced glycation end products (AGEs) is a major pathologic event in DR. While diabetes leads to a decr...

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Detalles Bibliográficos
Autores principales: Thompson, Kayla, Chen, Jonathan, Luo, Qianyi, Xiao, Yucheng, Cummins, Theodore R., Bhatwadekar, Ashay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825079/
https://www.ncbi.nlm.nih.gov/pubmed/29474462
http://dx.doi.org/10.1371/journal.pone.0193280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825079/
https://www.ncbi.nlm.nih.gov/pubmed/29474462
http://dx.doi.org/10.1371/journal.pone.0193280

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