A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of paclitaxel and 6α-hydroxy-paclitaxel in human plasma: Development, validation and application in a clinical pharmacokinetic study

Paclitaxel belongs to the taxanes family and it is used, alone or in multidrug regimens, for the therapy of several solid tumours, such as breast-, lung-, head and neck-, and ovarian cancer. Standard dosing of chemotherapy does not take into account the many inter-patient differences that make drug...

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Detalles Bibliográficos
Autores principales: Posocco, Bianca, Buzzo, Mauro, Follegot, Andrea, Giodini, Luciana, Sorio, Roberto, Marangon, Elena, Toffoli, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825125/
https://www.ncbi.nlm.nih.gov/pubmed/29474420
http://dx.doi.org/10.1371/journal.pone.0193500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825125/
https://www.ncbi.nlm.nih.gov/pubmed/29474420
http://dx.doi.org/10.1371/journal.pone.0193500

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