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Contribution of S4 segments and S4-S5 linkers to the low-voltage activation properties of T-type Ca(V)3.3 channels
Voltage-gated calcium channels contain four highly conserved transmembrane helices known as S4 segments that exhibit a positively charged residue every third position, and play the role of voltage sensing. Nonetheless, the activation range between high-voltage (HVA) and low-voltage (LVA) activated c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825144/ https://www.ncbi.nlm.nih.gov/pubmed/29474447 http://dx.doi.org/10.1371/journal.pone.0193490 |