Generation of efficient mutants of endoglycosidase from Streptococcus pyogenes and their application in a novel one-pot transglycosylation reaction for antibody modification

The fine structures of Fc N-glycan modulate the biological functions and physicochemical properties of antibodies. By remodeling N-glycan to obtain a homogeneous glycoform or chemically modified glycan, antibody characteristics can be controlled or modified. Such remodeling can be achieved by transg...

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Detalles Bibliográficos
Autores principales: Iwamoto, Mitsuhiro, Sekiguchi, Yukiko, Nakamura, Kensuke, Kawaguchi, Yoshirou, Honda, Takeshi, Hasegawa, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825150/
https://www.ncbi.nlm.nih.gov/pubmed/29474426
http://dx.doi.org/10.1371/journal.pone.0193534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825150/
https://www.ncbi.nlm.nih.gov/pubmed/29474426
http://dx.doi.org/10.1371/journal.pone.0193534

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