Structural insights into humanization of anti-tissue factor antibody 10H10

Murine antibody 10H10 raised against human tissue factor is unique in that it blocks the signaling pathway, and thus inhibits angiogenesis and tumor growth without interfering with coagulation. As a potential therapeutic, the antibody was humanized in a two-step procedure. Antigen-binding loops were...

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Detalles Bibliográficos
Autores principales: Teplyakov, Alexey, Obmolova, Galina, Malia, Thomas J., Raghunathan, Gopalan, Martinez, Christian, Fransson, Johan, Edwards, Wilson, Connor, Judith, Husovsky, Matthew, Beck, Heena, Chi, Ellen, Fenton, Sandra, Zhou, Hong, Almagro, Juan Carlos, Gilliland, Gary L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825201/
https://www.ncbi.nlm.nih.gov/pubmed/29283291
http://dx.doi.org/10.1080/19420862.2017.1412026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825201/
https://www.ncbi.nlm.nih.gov/pubmed/29283291
http://dx.doi.org/10.1080/19420862.2017.1412026

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