Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system

The blood-brain barrier (BBB) is a formidable obstacle for delivery of biologic therapeutics to central nervous system (CNS) targets. Whilst the BBB prevents passage of the vast majority of molecules, it also selectively transports a wide variety of molecules required to maintain brain homeostasis....

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Detalles Bibliográficos
Autores principales: Thom, George, Hatcher, Jon, Hearn, Arron, Paterson, Judy, Rodrigo, Natalia, Beljean, Arthur, Gurrell, Ian, Webster, Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825204/
https://www.ncbi.nlm.nih.gov/pubmed/29182455
http://dx.doi.org/10.1080/19420862.2017.1409320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825204/
https://www.ncbi.nlm.nih.gov/pubmed/29182455
http://dx.doi.org/10.1080/19420862.2017.1409320

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