Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform

BACKGROUND AND PURPOSE: Statins are amongst the most widely prescribed drugs for those at risk of cardiovascular disease, lowering cholesterol levels by inhibiting 3‐hydroxy‐3‐methylglutaryl (HMG)‐CoA reductase. Although effective at preventing cardiovascular disease, statin use is associated with m...

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Detalles Bibliográficos
Autores principales: Venturi, Elisa, Lindsay, Chris, Lotteau, Sabine, Yang, Zhaokang, Steer, Emma, Witschas, Katja, Wilson, Abigail D, Wickens, James R, Russell, Angela J, Steele, Derek, Calaghan, Sarah, Sitsapesan, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825303/
https://www.ncbi.nlm.nih.gov/pubmed/29278865
http://dx.doi.org/10.1111/bph.14136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825303/
https://www.ncbi.nlm.nih.gov/pubmed/29278865
http://dx.doi.org/10.1111/bph.14136

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