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The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival

Asna1, also known as TRC40, is implicated in the delivery of tail-anchored (TA) proteins into the endoplasmic reticulum (ER), in vesicle-mediated transport, and in chaperoning unfolded proteins during oxidative stress/ATP depletion. Here, we show that Asna1 inactivation in pancreatic progenitor cell...

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Detalles Bibliográficos
Autores principales: Norlin, Stefan, Parekh, Vishal, Edlund, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825870/
https://www.ncbi.nlm.nih.gov/pubmed/29180572
http://dx.doi.org/10.1242/dev.154468