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Revealing age-related changes of adult hippocampal neurogenesis using mathematical models

New neurons are continuously generated in the dentate gyrus of the adult hippocampus. This continuous supply of newborn neurons is important to modulate cognitive functions. Yet the number of newborn neurons declines with age. Increasing Wnt activity upon loss of dickkopf 1 can counteract both the d...

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Detalles Bibliográficos
Autores principales: Ziebell, Frederik, Dehler, Sascha, Martin-Villalba, Ana, Marciniak-Czochra, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5825879/
https://www.ncbi.nlm.nih.gov/pubmed/29229768
http://dx.doi.org/10.1242/dev.153544