Nucleoplasmic lamins define growth-regulating functions of lamina-associated polypeptide 2α in progeria cells

A-type lamins are components of the peripheral nuclear lamina but also localize in the nuclear interior in a complex with lamina-associated polypeptide (LAP) 2α. Loss of LAP2α and nucleoplasmic lamins in wild-type cells increases cell proliferation, but in cells expressing progerin (a mutant lamin A...

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Detalles Bibliográficos
Autores principales: Vidak, Sandra, Georgiou, Konstantina, Fichtinger, Petra, Naetar, Nana, Dechat, Thomas, Foisner, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826045/
https://www.ncbi.nlm.nih.gov/pubmed/29361532
http://dx.doi.org/10.1242/jcs.208462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826045/
https://www.ncbi.nlm.nih.gov/pubmed/29361532
http://dx.doi.org/10.1242/jcs.208462

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