Calcineurin B in CD4(+) T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway

Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and function. Here, we generated a conditional Cnb1 mouse model in which Cnb1 was specifically del...

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Detalles Bibliográficos
Autores principales: Mencarelli, Andrea, Vacca, Maurizio, Khameneh, Hanif Javanmard, Acerbi, Enzo, Tay, Alicia, Zolezzi, Francesca, Poidinger, Michael, Mortellaro, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826051/
https://www.ncbi.nlm.nih.gov/pubmed/29515579
http://dx.doi.org/10.3389/fimmu.2018.00261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826051/
https://www.ncbi.nlm.nih.gov/pubmed/29515579
http://dx.doi.org/10.3389/fimmu.2018.00261

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