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Calcineurin B in CD4(+) T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway
Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and function. Here, we generated a conditional Cnb1 mouse model in which Cnb1 was specifically del...
Autores principales: | Mencarelli, Andrea, Vacca, Maurizio, Khameneh, Hanif Javanmard, Acerbi, Enzo, Tay, Alicia, Zolezzi, Francesca, Poidinger, Michael, Mortellaro, Alessandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826051/ https://www.ncbi.nlm.nih.gov/pubmed/29515579 http://dx.doi.org/10.3389/fimmu.2018.00261 |
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