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Modeling Protein Aggregation and the Heat Shock Response in ALS iPSC-Derived Motor Neurons

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder caused by the selective loss of the upper and lower motor neurons. Only 10% of all cases are caused by a mutation in one of the two dozen different identified genes, while the remaining 90% are likely caused by a combina...

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Detalles Bibliográficos
Autores principales:	Seminary, Emily R., Sison, Samantha L., Ebert, Allison D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826239/ https://www.ncbi.nlm.nih.gov/pubmed/29515358 http://dx.doi.org/10.3389/fnins.2018.00086

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