NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus

Diurnal oscillation of intracellular redox potential is known to couple metabolism with the circadian clock, yet the responsible mechanisms are not well understood. We show here that chemical activation of NRF2 modifies circadian gene expression and rhythmicity, with phenotypes similar to genetic NR...

Descripción completa

Detalles Bibliográficos
Autores principales: Wible, Ryan S, Ramanathan, Chidambaram, Sutter, Carrie Hayes, Olesen, Kristin M, Kensler, Thomas W, Liu, Andrew C, Sutter, Thomas R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826263/
https://www.ncbi.nlm.nih.gov/pubmed/29481323
http://dx.doi.org/10.7554/eLife.31656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826263/
https://www.ncbi.nlm.nih.gov/pubmed/29481323
http://dx.doi.org/10.7554/eLife.31656

Ejemplares similares