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Extreme heterogeneity of influenza virus infection in single cells

Viral infection can dramatically alter a cell’s transcriptome. However, these changes have mostly been studied by bulk measurements on many cells. Here we use single-cell mRNA sequencing to examine the transcriptional consequences of influenza virus infection. We find extremely wide cell-to-cell var...

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Detalles Bibliográficos
Autores principales: Russell, Alistair B, Trapnell, Cole, Bloom, Jesse D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826275/
https://www.ncbi.nlm.nih.gov/pubmed/29451492
http://dx.doi.org/10.7554/eLife.32303