17-AAG inhibits vemurafenib-associated MAP kinase activation and is synergistic with cellular immunotherapy in a murine melanoma model

Heat shock protein 90 (HSP90) is a molecular chaperone which stabilizes client proteins with important roles in tumor growth. 17-allylamino-17-demethoxygeldanamycin (17-AAG), an inhibitor of HSP90 ATPase activity, occupies the ATP binding site of HSP90 causing a conformational change which destabili...

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Detalles Bibliográficos
Autores principales: Joshi, Sandeep S., Jiang, Shunlin, Unni, Emmanual, Goding, Stephen R., Fan, Tao, Antony, Paul A., Hornyak, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826531/
https://www.ncbi.nlm.nih.gov/pubmed/29481571
http://dx.doi.org/10.1371/journal.pone.0191264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826531/
https://www.ncbi.nlm.nih.gov/pubmed/29481571
http://dx.doi.org/10.1371/journal.pone.0191264

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