SIRT6 deacetylates H3K18Ac at pericentric chromatin to prevent mitotic errors and cell senescence

Pericentric heterochromatin silencing at mammalian centromeres is essential for mitotic fidelity and genomic stability. Defective pericentric silencing is observed in senescent cells, aging tissues, and mammalian tumors, but the underlying mechanisms and functional consequences of these defects are...

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Detalles Bibliográficos
Autores principales: Tasselli, Luisa, Xi, Yuanxin, Zheng, Wei, Tennen, Ruth I., Odrowaz, Zaneta, Simeoni, Federica, Li, Wei, Chua, Katrin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826646/
https://www.ncbi.nlm.nih.gov/pubmed/27043296
http://dx.doi.org/10.1038/nsmb.3202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826646/
https://www.ncbi.nlm.nih.gov/pubmed/27043296
http://dx.doi.org/10.1038/nsmb.3202

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