Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine

One of the main obstacles for cancer therapies is to deliver medicines effectively to target sites. Since stroma cells are developed around tumors, chemotherapeutic agents have to go through stroma cells in order to reach tumors. As a method to improve drug delivery to the tumor site, a prodrug appr...

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Detalles Bibliográficos
Autores principales: Tsume, Yasuhiro, Drelich, Adam J., Smith, David E., Amidon, Gordon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826767/
https://www.ncbi.nlm.nih.gov/pubmed/28796151
http://dx.doi.org/10.3390/molecules22081322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826767/
https://www.ncbi.nlm.nih.gov/pubmed/28796151
http://dx.doi.org/10.3390/molecules22081322

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