A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the transfer of a methyl group from the co-factor S-adenosyl-L-methionine (SAM) onto the substrate, nicotinamide (NA) to form 1-methyl-nicotinamide (MNA). Higher NNMT expression and MNA concentrations have been associated w...

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Detalles Bibliográficos
Autores principales: Kannt, Aimo, Rajagopal, Sridharan, Kadnur, Sanjay Venkatachalapathi, Suresh, Juluri, Bhamidipati, Ravi Kanth, Swaminathan, Srinivasan, Hallur, Mahanandeesha Siddappa, Kristam, Rajendra, Elvert, Ralf, Czech, Jörg, Pfenninger, Anja, Rudolph, Christine, Schreuder, Herman, Chandrasekar, Devaraj Venkatapura, Mane, Vishal Subhash, Birudukota, Swarnakumari, Shaik, Shama, Zope, Bharat Ravindra, Burri, Raghunadha Reddy, Anand, Niranjan Naranapura, Thakur, Manish Kumar, Singh, Manvi, Parveen, Reejuana, Kandan, Saravanan, Mullangi, Ramesh, Yura, Takeshi, Gosu, Ramachandraiah, Ruf, Sven, Dhakshinamoorthy, Saravanakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826917/
https://www.ncbi.nlm.nih.gov/pubmed/29483571
http://dx.doi.org/10.1038/s41598-018-22081-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826917/
https://www.ncbi.nlm.nih.gov/pubmed/29483571
http://dx.doi.org/10.1038/s41598-018-22081-7

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