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Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling

Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related prote...

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Detalles Bibliográficos
Autores principales: Bartelt, Alexander, Behler-Janbeck, Friederike, Beil, F. Timo, Koehne, Till, Müller, Brigitte, Schmidt, Tobias, Heine, Markus, Ochs, Laura, Yilmaz, Tayfun, Dietrich, Martin, Tuckermann, Jan P., Amling, Michael, Herz, Joachim, Schinke, Thorsten, Heeren, Joerg, Niemeier, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826921/
https://www.ncbi.nlm.nih.gov/pubmed/29507818
http://dx.doi.org/10.1038/s41413-017-0006-3