Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs

NSAIDs inhibit tumorigenesis in gastrointestinal tissues and have been proposed as coadjuvant agents to chemotherapy. The ability of cancer epithelial cells to adapt to the tumour environment and to resist cytotoxic agents seems to depend on rescue mechanisms such as autophagy. In the present study...

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Detalles Bibliográficos
Autores principales: Vallecillo-Hernández, Jorge, Barrachina, Maria Dolores, Ortiz-Masiá, Dolores, Coll, Sandra, Esplugues, Juan Vicente, Calatayud, Sara, Hernández, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827024/
https://www.ncbi.nlm.nih.gov/pubmed/29483523
http://dx.doi.org/10.1038/s41598-018-21455-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827024/
https://www.ncbi.nlm.nih.gov/pubmed/29483523
http://dx.doi.org/10.1038/s41598-018-21455-1

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