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Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs
NSAIDs inhibit tumorigenesis in gastrointestinal tissues and have been proposed as coadjuvant agents to chemotherapy. The ability of cancer epithelial cells to adapt to the tumour environment and to resist cytotoxic agents seems to depend on rescue mechanisms such as autophagy. In the present study...
Autores principales: | Vallecillo-Hernández, Jorge, Barrachina, Maria Dolores, Ortiz-Masiá, Dolores, Coll, Sandra, Esplugues, Juan Vicente, Calatayud, Sara, Hernández, Carlos |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827024/ https://www.ncbi.nlm.nih.gov/pubmed/29483523 http://dx.doi.org/10.1038/s41598-018-21455-1 |
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