H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses

Metformin is the most widely used anti-diabetic medication worldwide. However, human and animal studies suggest that prenatal metformin exposure may increase the risk of metabolic disorders in adult offspring, yet the underpinning mechanism remains unclear. Here we report that metformin-exposed mous...

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Detalles Bibliográficos
Autores principales: Deng, Jie, Mueller, Martin, Geng, Tingting, Shen, Yuanyuan, Liu, Ya, Hou, Peng, Ramillapalli, Ramanaiah, Taylor, Hugh S, Paidas, Michael, Huang, Yingqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827203/
https://www.ncbi.nlm.nih.gov/pubmed/29215608
http://dx.doi.org/10.1038/cddis.2017.392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827203/
https://www.ncbi.nlm.nih.gov/pubmed/29215608
http://dx.doi.org/10.1038/cddis.2017.392

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