Using genetic buffering relationships identified in fission yeast to reveal susceptibilities in cells lacking hamartin or tuberin function

Tuberous sclerosis complex is an autosomal dominant disorder characterized by benign tumors arising from the abnormal activation of mTOR signaling in cells lacking TSC1 (hamartin) or TSC2 (tuberin) activity. To expand the genetic framework surrounding this group of growth regulators, we utilized the...

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Detalles Bibliográficos
Autores principales: Rayhan, Ashyad, Faller, Adam, Chevalier, Ryan, Mattice, Alannah, Karagiannis, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827267/
https://www.ncbi.nlm.nih.gov/pubmed/29343513
http://dx.doi.org/10.1242/bio.031302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827267/
https://www.ncbi.nlm.nih.gov/pubmed/29343513
http://dx.doi.org/10.1242/bio.031302

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