Simultaneous Insertion of Two Ligands in gD for Cultivation of Oncolytic Herpes Simplex Viruses in Noncancer Cells and Retargeting to Cancer Receptors

Insertion of a single-chain variable-fragment antibody (scFv) to HER2 (human epidermal growth factor receptor 2) in gD, gH, or gB gives rise to herpes simplex viruses (HSVs) specifically retargeted to HER2-positive cancer cells, hence to highly specific nonattenuated oncolytic agents. Clinical-grade...

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Detalles Bibliográficos
Autores principales: Leoni, Valerio, Petrovic, Biljana, Gianni, Tatiana, Gatta, Valentina, Campadelli-Fiume, Gabriella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Gene Delivery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827369/
https://www.ncbi.nlm.nih.gov/pubmed/29263255
http://dx.doi.org/10.1128/JVI.02132-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827369/
https://www.ncbi.nlm.nih.gov/pubmed/29263255
http://dx.doi.org/10.1128/JVI.02132-17

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