Lactate-Induced Glucose Output Is Unchanged by Metformin at a Therapeutic Concentration – A Mass Spectrometry Imaging Study of the Perfused Rat Liver

Metformin is the first line drug for type 2 diabetes but its molecular mechanisms remain unclear. Here, we have studied the acute effect of a therapeutically relevant intrahepatic concentration of metformin on glucose production from lactate. We selected the perfused rat liver as experimental system...

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Detalles Bibliográficos
Autores principales: Calza, Giulio, Nyberg, Elisabeth, Mäkinen, Matias, Soliymani, Rabah, Cascone, Annunziata, Lindholm, Dan, Barborini, Emanuele, Baumann, Marc, Lalowski, Maciej, Eriksson, Ove
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827415/
https://www.ncbi.nlm.nih.gov/pubmed/29520235
http://dx.doi.org/10.3389/fphar.2018.00141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827415/
https://www.ncbi.nlm.nih.gov/pubmed/29520235
http://dx.doi.org/10.3389/fphar.2018.00141

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