A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

STIM1 and Orai1 are key components of the Ca(2+)-release activated Ca(2+) (CRAC) current. Orai1, which represents the subunit forming the CRAC channel complex, is activated by the ER resident Ca(2+) sensor STIM1. The genetically inherited Stormorken syndrome disease has been associated with the STIM...

Descripción completa

Detalles Bibliográficos
Autores principales: Fahrner, Marc, Stadlbauer, Michael, Muik, Martin, Rathner, Petr, Stathopulos, Peter, Ikura, Mitsu, Müller, Norbert, Romanin, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827659/
https://www.ncbi.nlm.nih.gov/pubmed/29483506
http://dx.doi.org/10.1038/s41467-018-03062-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827659/
https://www.ncbi.nlm.nih.gov/pubmed/29483506
http://dx.doi.org/10.1038/s41467-018-03062-w

Ejemplares similares