Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation

Drug-induced perturbations of the endogenous metabolic network are a potential root cause of cellular toxicity. A mechanistic understanding of such unwanted side effects during drug therapy is therefore vital for patient safety. The comprehensive assessment of such drug-induced injuries requires the...

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Detalles Bibliográficos
Autores principales: Cordes, Henrik, Thiel, Christoph, Baier, Vanessa, Blank, Lars M., Kuepfer, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827733/
https://www.ncbi.nlm.nih.gov/pubmed/29507756
http://dx.doi.org/10.1038/s41540-018-0048-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827733/
https://www.ncbi.nlm.nih.gov/pubmed/29507756
http://dx.doi.org/10.1038/s41540-018-0048-1

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