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The efficacy of Ranolazine on E1784K is altered by temperature and calcium

E1784K is the most common mixed syndrome SCN5a mutation underpinning both Brugada syndrome type 1 (BrS1) and Long-QT syndrome type 3 (LQT3). The charge reversal mutant enhances the late sodium current (I(Na)) passed by the cardiac voltage-gated sodium channel (Na(V)1.5), delaying cardiac repolarizat...

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Detalles Bibliográficos
Autores principales: Abdelsayed, Mena, Ruprai, Manpreet, Ruben, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827758/
https://www.ncbi.nlm.nih.gov/pubmed/29483621
http://dx.doi.org/10.1038/s41598-018-22033-1