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The efficacy of Ranolazine on E1784K is altered by temperature and calcium
E1784K is the most common mixed syndrome SCN5a mutation underpinning both Brugada syndrome type 1 (BrS1) and Long-QT syndrome type 3 (LQT3). The charge reversal mutant enhances the late sodium current (I(Na)) passed by the cardiac voltage-gated sodium channel (Na(V)1.5), delaying cardiac repolarizat...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827758/ https://www.ncbi.nlm.nih.gov/pubmed/29483621 http://dx.doi.org/10.1038/s41598-018-22033-1 |