Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing

Oligonucleotides (ONs) have been envisaged for therapeutic applications for more than thirty years. However, their broad use requires overcoming several hurdles such as instability in biological fluids, low cell penetration, limited tissue distribution, and off-target effects. With this aim, many ch...

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Detalles Bibliográficos
Autores principales: Debart, Françoise, Dupouy, Christelle, Vasseur, Jean-Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827813/
https://www.ncbi.nlm.nih.gov/pubmed/29520308
http://dx.doi.org/10.3762/bjoc.14.32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827813/
https://www.ncbi.nlm.nih.gov/pubmed/29520308
http://dx.doi.org/10.3762/bjoc.14.32

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