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Stimuli-responsive oligonucleotides in prodrug-based approaches for gene silencing
Oligonucleotides (ONs) have been envisaged for therapeutic applications for more than thirty years. However, their broad use requires overcoming several hurdles such as instability in biological fluids, low cell penetration, limited tissue distribution, and off-target effects. With this aim, many ch...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827813/ https://www.ncbi.nlm.nih.gov/pubmed/29520308 http://dx.doi.org/10.3762/bjoc.14.32 |