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Continuous multistep synthesis of 2-(azidomethyl)oxazoles

An efficient three-step protocol was developed to produce 2-(azidomethyl)oxazoles from vinyl azides in a continuous-flow process. The general synthetic strategy involves a thermolysis of vinyl azides to generate azirines, which react with bromoacetyl bromide to provide 2-(bromomethyl)oxazoles. The l...

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Detalles Bibliográficos
Autores principales: Rossa, Thaís A, Suveges, Nícolas S, Sá, Marcus M, Cantillo, David, Kappe, C Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827817/
https://www.ncbi.nlm.nih.gov/pubmed/29520312
http://dx.doi.org/10.3762/bjoc.14.36