A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis

Given its role as the source of definitive hematopoietic cells, we sought to determine whether mutations initiated in the hemogenic endothelium would yield hematopoietic abnormalities or malignancies. Here, we find that endothelium-specific transposon mutagenesis in mice promotes hematopoietic patho...

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Detalles Bibliográficos
Autores principales: Ziyad, Safiyyah, Riordan, Jesse D., Cavanaugh, Ann M., Su, Trent, Hernandez, Gloria E., Hilfenhaus, Georg, Morselli, Marco, Huynh, Kristine, Wang, Kevin, Chen, Jau-Nian, Dupuy, Adam J., Iruela-Arispe, M. Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828030/
https://www.ncbi.nlm.nih.gov/pubmed/29386109
http://dx.doi.org/10.1016/j.celrep.2018.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828030/
https://www.ncbi.nlm.nih.gov/pubmed/29386109
http://dx.doi.org/10.1016/j.celrep.2018.01.017

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