Combining expression of GPC3 in tumors and CD16 on NK cells from peripheral blood to identify patients responding to codrituzumab

BACKGROUND: Codrituzumab, a monoclonal antibody targeting an oncofetal protein glypican-3 (GPC3) expressed on cell surface of hepatocellular carcinoma (HCC) induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth in preclinical studies. Based on this mechanism, tumor GPC3 e...

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Detalles Bibliográficos
Autores principales: Chen, Gong, Chen, Ya-Chi, Reis, Bernhard, Belousov, Anton, Jukofsky, Lori, Rossin, Christine, Muehlig, Axel, Xu, Chao, Essioux, Laurent, Ohtomo, Toshihiko, Di Laurenzio, Laura, Puig, Oscar, Lee, Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828203/
https://www.ncbi.nlm.nih.gov/pubmed/29535817
http://dx.doi.org/10.18632/oncotarget.23830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828203/
https://www.ncbi.nlm.nih.gov/pubmed/29535817
http://dx.doi.org/10.18632/oncotarget.23830

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