Cargando…

Severe hypoxia selects hematopoietic progenitors with stem cell potential from primary Myelodysplastic syndrome bone marrow cell cultures

Myelodysplastic Syndromes (MDS) are clonal neoplasms where stem/progenitor cells endowed with self-renewal and capable of perpetuating the disease have been demonstrated. It is known that oxygen tension plays a key role in driving normal hematopoiesis and that hematopoietic stem cells are maintained...

Descripción completa

Detalles Bibliográficos
Autores principales:	Masala, Erico, Valencia-Martinez, Ana, Pillozzi, Serena, Rondelli, Tommaso, Brogi, Alice, Sanna, Alessandro, Gozzini, Antonella, Arcangeli, Annarosa, Sbarba, Persio Dello, Santini, Valeria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828219/ https://www.ncbi.nlm.nih.gov/pubmed/29535827 http://dx.doi.org/10.18632/oncotarget.24302

Ejemplares similares

The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction
por: Cheloni, Giulia, et al.
Publicado: (2017)

Hypoxia Selects Bortezomib-Resistant Stem Cells of Chronic Myeloid Leukemia
por: Tanturli, Michele, et al.
Publicado: (2011)

Time- and residue-specific differences in histone acetylation induced by VPA and SAHA in AML1/ETO-positive leukemia cells
por: Barbetti, Valentina, et al.
Publicado: (2013)

Correction to Barbetti V, et al. Epigenetics Volume 8, Issue 2; pp. 210–9
por: Barbetti, Valentina, et al.
Publicado: (2013)

Redistribution of H3K27me3 and acetylated histone H4 upon exposure to azacitidine and decitabine results in de-repression of the AML1/ETO target gene IL3
por: Buchi, Francesca, et al.
Publicado: (2014)

The Culture-Repopulating Ability Assays and Incubation in Low Oxygen: A Simple Way to Test Drugs on Leukaemia Stem or Progenitor Cells
por: Cipolleschi, Maria Grazia, et al.
Publicado: (2013)

In Vitro Comparison of the Effects of Imatinib and Ponatinib on Chronic Myeloid Leukemia Progenitor/Stem Cell Features
por: Tusa, Ignazia, et al.
Publicado: (2020)

Circulating Endothelial Progenitor Cells in Type 1 Diabetic Patients: Relation with Patients’ Age and Disease Duration
por: Arcangeli, Adolfo, et al.
Publicado: (2017)

Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine
por: Valencia, A, et al.
Publicado: (2014)

Cancer stemness and progression: mitochondria on the stage
por: Chiarugi, Paola, et al.
Publicado: (2015)

Sensitivity to imatinib of KCL22 chronic myeloid leukemia cell survival/growth and stem cell potential under glucose shortage
por: Bono, Silvia, et al.
Publicado: (2018)

Data describing the effects of the Macrolide Antibiotic Clarithromycin on preclinical mouse models of Colorectal Cancer
por: Petroni, Giulia, et al.
Publicado: (2019)

Chronic myeloid leukemia progenitor cells require autophagy when leaving hypoxia-induced quiescence
por: Ianniciello, Angela, et al.
Publicado: (2017)

Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets
por: Cipolleschi, Maria Grazia, et al.
Publicado: (2014)

Chronic Myeloid Leukemia and Hepatoblastoma: Two Cancer Models to Link Metabolism to Stem Cells
por: Cipolleschi, Maria Grazia, et al.
Publicado: (2016)

One more stem cell niche: how the sensitivity of chronic myeloid leukemia cells to imatinib mesylate is modulated within a “hypoxic” environment
por: Rovida, Elisabetta, et al.
Publicado: (2014)

Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway
por: Fortunato, Pina, et al.
Publicado: (2010)

Ion Channels in Hematopoietic and Mesenchymal Stem Cells
por: Pillozzi, Serena, et al.
Publicado: (2012)

The Colony-Stimulating Factor-1 (CSF-1) Receptor Sustains ERK1/2 Activation and Proliferation in Breast Cancer Cell Lines
por: Morandi, Andrea, et al.
Publicado: (2011)

Beyond Kinase Activity: ERK5 Nucleo-Cytoplasmic Shuttling as a Novel Target for Anticancer Therapy
por: Tubita, Alessandro, et al.
Publicado: (2020)

Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells
por: Tusa, Ignazia, et al.
Publicado: (2018)

Serum Inflamma-miR Signature: A Biomarker of Myelodysplastic Syndrome?
por: Mariani, Marianna, et al.
Publicado: (2020)

Myelodysplastic syndromes are multiclonal diseases derived from hematopoietic stem and progenitor cells
por: Luo, Bingqing, et al.
Publicado: (2022)

S162: LOSS OF HEMATOPOIETIC PROGENITORS HETEROGENEITY IS AN ADVERSE PROGNOSTIC FACTOR IN MYELODYSPLASTIC SYNDROMES
por: Dussiau, Charles, et al.
Publicado: (2023)

Low-dose methotrexate enhances cycling of highly anaplastic cancer cells
por: Cipolleschi, Maria Grazia, et al.
Publicado: (2016)

Over-Expression of the LH Receptor Increases Distant Metastases in an Endometrial Cancer Mouse Model
por: Pillozzi, Serena, et al.
Publicado: (2013)

Transgenic mice overexpressing the LH receptor in the female reproductive system spontaneously develop endometrial tumour masses
por: Lottini, Tiziano, et al.
Publicado: (2021)

AML1/ETO sensitizes via TRAIL acute myeloid leukemia cells to the pro-apoptotic effects of hypoxia
por: Barbetti, V, et al.
Publicado: (2013)

Glutamine Availability Controls BCR/Abl Protein Expression and Functional Phenotype of Chronic Myeloid Leukemia Cells Endowed with Stem/Progenitor Cell Potential
por: Poteti, Martina, et al.
Publicado: (2021)

Pro-inflammatory proteins S100A9 and tumor necrosis factor-α suppress erythropoietin elaboration in myelodysplastic syndromes
por: Cluzeau, Thomas, et al.
Publicado: (2017)

Tumor-selective peptide-carrier delivery of Paclitaxel increases in vivo activity of the drug
por: Brunetti, Jlenia, et al.
Publicado: (2015)

The ion channels and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma
por: Magi, Alberto, et al.
Publicado: (2019)

Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality
por: Dimitriou, Marios, et al.
Publicado: (2016)

VEGF Receptor 1 Promotes Hypoxia-Induced Hematopoietic Progenitor Proliferation and Differentiation
por: Florentin, Jonathan, et al.
Publicado: (2022)

LH/hCG-Receptor Expression May Have a Negative Prognostic Value in Low-Risk Endometrial Cancer
por: Noci, Ivo, et al.
Publicado: (2016)

Assessment of Drug Sensitivity in Hematopoietic Stem and Progenitor Cells from Acute Myelogenous Leukemia and Myelodysplastic Syndrome Ex Vivo
por: Knorr, Katherine L.B., et al.
Publicado: (2016)

The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells
por: Tusa, Ignazia, et al.
Publicado: (2021)

Circulating miRNome profiling data in Behçet's syndrome
por: Bagni, Giacomo, et al.
Publicado: (2021)

Dysfunctional bone marrow endothelial progenitor cells are involved in patients with myelodysplastic syndromes
por: Xing, Tong, et al.
Publicado: (2022)

Role and Timing of Hematopoietic Cell Transplantation for Myelodysplastic Syndrome
por: Field, Teresa, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_mie2rgil07btsm0god0ev3sqg0