HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog

Hypoxic and stroma-rich microenvironments, characteristic features of pancreatic cancers, are strongly associated with a poor prognosis. However, whether and how hypoxia increases stromal compartments remain largely unknown. Here, we investigated the potential importance of a master regulator of the...

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Detalles Bibliográficos
Autores principales: Katagiri, Tomohiro, Kobayashi, Minoru, Yoshimura, Michio, Morinibu, Akiyo, Itasaka, Satoshi, Hiraoka, Masahiro, Harada, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828220/
https://www.ncbi.nlm.nih.gov/pubmed/29535824
http://dx.doi.org/10.18632/oncotarget.24156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828220/
https://www.ncbi.nlm.nih.gov/pubmed/29535824
http://dx.doi.org/10.18632/oncotarget.24156

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